https://sherishterner.nextbb.ru/ общение для тех кто столкнулся с синдромом Шеришевского- Тернера ru-ru Fri, 29 Dec 2023 09:22:54 +0300 MyBB/mybb.ru https://sherishterner.nextbb.ru/viewtopic.php?pid=77#p77 <p><span style="display: block; text-align: center"><strong><span style="font-size: 24px">Профессиональные услуги клининга</span></strong></span>&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 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Мы также предлагаем ЭКО-чистку детских игрушек, колясок, комнат и различных предметов. Заказ по тел. +7 915 204 1047 Наш канал: t.me/wwcleaning Москва и Московская область</span></span>&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 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&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; <span style="display: block; text-align: center"><span style="font-size: 16px"><a href="https://u.to/erY0IA" rel="nofollow" target="_blank">Перейти</a></span></span></p> mybb@mybb.ru (yoxeyxkepa) Fri, 29 Dec 2023 09:22:54 +0300 https://sherishterner.nextbb.ru/viewtopic.php?pid=77#p77 https://sherishterner.nextbb.ru/viewtopic.php?pid=76#p76 <p>Технология восстановления зубов &quot;All-on-4&quot; - это современный метод имплантации и протезирования, который позволяет восстановить все зубы челюсти за 1 день без необходимости выполнения остеопластики - наращивания костной ткани. <a href="https://americandental.ru/all-on-4/" rel="nofollow" target="_blank">https://americandental.ru/all-on-4/</a> &#9989; Лечение выполняется без остеопластики при атрофии легкой и средней степени&#160; &#9989; Установка имплантов производится через прокол, а не разрез, таким образом, реабилитация быстрее и проще &#9989; Пожилой возраст не является препятствием для операции &#9989; Установка эстетичного несъемного протеза возможна уже через 4-6 часов, таким образом, нет необходимости ожидать 4-6 месяцев как при восстановлении зубов двухэтапным способом &#9989; На время лечения и реабилитации нет необходимости отказываться от привычного образа жизни &#9989; Так как жевательная нагрузка начинает подаваться практически сразу после операции, обменные процессы активизируются, и атрофия прекращается &#9989; Стоимость восстановления зубов &quot;All-on-4&quot; существенно ниже, чем цена классического протезирования аналогичного количества зубов. Перейти:&#160; <a href="https://is.gd/vAAwhn" rel="nofollow" target="_blank">https://is.gd/vAAwhn</a></p> mybb@mybb.ru (yoxeyxkepa) Wed, 30 Aug 2023 02:36:11 +0300 https://sherishterner.nextbb.ru/viewtopic.php?pid=76#p76 https://sherishterner.nextbb.ru/viewtopic.php?pid=75#p75 <p>Технология восстановления зубов &quot;All-on-4&quot; - это современный метод имплантации и протезирования, который позволяет восстановить все зубы челюсти за 1 день без необходимости выполнения остеопластики - наращивания костной ткани. <a href="https://americandental.ru/all-on-4/" rel="nofollow" target="_blank">https://americandental.ru/all-on-4/</a> &#9989; Лечение выполняется без остеопластики при атрофии легкой и средней степени&#160; &#9989; Установка имплантов производится через прокол, а не разрез, таким образом, реабилитация быстрее и проще &#9989; Пожилой возраст не является препятствием для операции &#9989; Установка эстетичного несъемного протеза возможна уже через 4-6 часов, таким образом, нет необходимости ожидать 4-6 месяцев как при восстановлении зубов двухэтапным способом &#9989; На время лечения и реабилитации нет необходимости отказываться от привычного образа жизни &#9989; Так как жевательная нагрузка начинает подаваться практически сразу после операции, обменные процессы активизируются, и атрофия прекращается &#9989; Стоимость восстановления зубов &quot;All-on-4&quot; существенно ниже, чем цена классического протезирования аналогичного количества зубов. Перейти:&#160; <a href="https://is.gd/vAAwhn" rel="nofollow" target="_blank">https://is.gd/vAAwhn</a></p> mybb@mybb.ru (yoxeyxkepa) Wed, 30 Aug 2023 00:19:56 +0300 https://sherishterner.nextbb.ru/viewtopic.php?pid=75#p75 https://sherishterner.nextbb.ru/viewtopic.php?pid=74#p74 <p>Избавление от вируса гепатита С обеспечивают новые лекарства.<br />Стремление к здоровому образу жизни стало настоящим трендом. Интерес к здоровью породил и стремление узнать побольше об опасностях, которые ему грозят. Наибольшей угрозой сегодня принято считать вирус гепатита С, этот возбудитель способен спровоцировать тяжелое хроническое заболевание, еще недавно считавшееся неизлечимым.</p> <p> Избавиться от угрозы помогает препарат Ледипасвир, его использование обеспечивает устранение вируса. Оно не является ни профилактическим средством, ни панацеей от любой разновидности вируса. Средство это комплексное, значит, содержит несколько активных компонентов.</p> <p>Почти все болезни проще предупредить, чем лечить. Это в полной мере можно сказать о ХВГС, являющимся прямым следствием вирусной инфекции. Предупредить осложнения помогает регулярная диагностика. Считается, что вирус излечим на ранних стадиях, вероятность его уничтожения близка к ста процентам. С годами и получаемыми проявлениями болезни, остается все меньше шансов на возвращение здоровья.<br />Ведение здорового образа жизни не становится защитой от вирусных инфекций, поэтому проходить обследование следует каждому. Проникновение возбудителей часто остается незамеченным, происходит при таких обычных обстоятельствах, как маникюр или лечение зубов.</p> <p>Чтобы выздороветь от гепатита С, необходимо использовать качественные и современные лекарства.<br /> </p> <p>Бесплатный звонок из России 8 (800) 302-78-98<br />Для звонков из других стран - +7 (495) 266-64-48</p> <p>Информация по ссылке : <a href="https://gepa-net.com/ledipasvir.html" rel="nofollow" target="_blank">https://gepa-net.com/ledipasvir.html</a> </p> <p>Email:info@gepa-net.com</p> mybb@mybb.ru (gepanett) Sun, 30 Sep 2018 19:08:49 +0300 https://sherishterner.nextbb.ru/viewtopic.php?pid=74#p74 https://sherishterner.nextbb.ru/viewtopic.php?pid=73#p73 <p>Здравствуйте Людмила! Увидела ваш форум решила зарегистрироваться так,как сама с СШТ.Меня зовут Юлия мне 30лет,живу в Киеве диагноз поставили в 14 лет.Буду рада общению</p> mybb@mybb.ru (Julia) Thu, 10 Jul 2014 15:56:57 +0400 https://sherishterner.nextbb.ru/viewtopic.php?pid=73#p73 https://sherishterner.nextbb.ru/viewtopic.php?pid=68#p68 <p>группа в Одноклассниках - &quot;Древо жизни - группа СШТ&quot;,ОНА ПОЛНОСТЬЮ ЗАКРЫТА,НАС там около 50 человек,все конфиденциально от посторонних,для вступления в группу вместе с подачей заявки обязательно необходимо написать поподробнее о своей ситуации администратору группы (в личку),а еще в профиле обязательно должна быть ваша личная фотография,анкета профиля должна быть по максимуму заполнена,больше доверия вызывают те странички,по которым видно,что человек ими реально пользуется и они не левые.Добро пожаловать всем желающим!</p> mybb@mybb.ru (LudmilaOdessa) Mon, 22 Oct 2012 00:35:03 +0400 https://sherishterner.nextbb.ru/viewtopic.php?pid=68#p68 https://sherishterner.nextbb.ru/viewtopic.php?pid=58#p58 <p>Фертильность у женщин с синдромом Шерешевского-Тернера.<br />Журнал &quot;Проблемы репродукции&quot; &gt; Номера журнала за 2000 год &gt; №2 &gt; Фертильность у женщин с синдромом Шерешевского-Тернера.</p> <p>Фертильность у женщин с синдромом Шерешевского-Тернера.<br /></p> <p>Словарь<br />Кариотип – полный набор хромосом диплоидной клетки (кариотип человека в норме 46,ХХ или 46,ХY).<br />Фенотип – совокупность признаков организма, контролируемый определенным генотипом.<br />Стигмы – фенотипические отклонения от нормального развития.<br />Фертильность – детородная функция живого организма.</p> <p>Гоносомы – половые хромосомы это Х- и Y-хромосома.<br />Моносомия – утрата целой хромосомы.<br />Стреки – соединительнотканные тяжи.<br />Центромера – органоид, располагающийся в районе первичной перетяжки хромосомы. Она делит хромосому на два плеча.<br />Теломера – концевой участок хромосомы. Специализированная структура, обеспечивающая стабильность линейной молекулы ДНК.<br />Делеция – утрата участка хромосомы.<br />Дисгенезия –нарушение формирования половой железы и вторичных признаков пола.</p> <p>Полная или частичная потеря одной хромосомы Х ведет большинстве случаев к абсолютному бесплодию. Но в 1960 г. F.Bahner и соавт. [2] впервые сообщили о фертильности у пациентки с синдромом Шерешевского–Тернера и с кариотипом 45,Х0. С этого времени описано более 100 беременностей у женщин с синдромом Шерешевского–Тернера. При этом беременные имели в большинстве гоносомальный мозаицизм между одной клеточной линией с различной аберрантной хромосомой Х или моносомией Х и одной нормальной линией клеток 46,ХХ, причем отношения обеих клеточных линий были различными. Дети матерей с мозаицизмом, например 46,ХХ/45,Х, имели как нормальный кариотип [13], так и аберрантный гоносомальный клон клеток [3]. Эти данные говорят, что потеря одной полной хромосомы Х или какой-то одной части хромосомы Х, не в каждом случае должна сопровождаться бесплодием [3, 14].</p> <p>Приводим наши наблюдения фертильности у женщин с бесплодием, невынашиванием, имеющих детей с врожденными пороками развития в анамнезе, с мозаичным кариотипом 46,ХХ/45,Х.</p> <p>Больная К. обратилась в медико-генетический центр 26.07.95 с целью генетического обследования и решения вопроса о прогнозе будущего потомства.</p> <p>Из акушерского анамнеза выяснено, что 29.08.95 в сроке 26–27 нед была прервана беременность. Причиной для прерывания беременности послужило заключение ультразвукового исследования (УЗИ), которое выявило множественные врожденные пороки развития плода: укорочение нижних конечностей, двухкамерное сердце, гидроцефалия. После прерывания беременности у плода мужского пола, массой 0,925 кг, были установлены все выявленные на УЗИ пороки развития.</p> <p>Из анамнеза женщины: менархе в 12 лет, месячные спонтанные, регулярные, через 24 дня по 3 дня, безболезненные, умеренные. Половая жизнь с 21 года. Беременность наступила спонтанно в течение первого года регулярной половой жизни и закончилась 29.08.95 в сроке 26–27 нед прерыванием беременности по медицинским показаниям.</p> <p>Через 2 года после индукции овуляции клостильбегитом в дозе 50 мг в день с 5-го по 9-й день цикла наступила беременность. При медико-генетическом консультировании рекомендовано проведение комплекса мероприятий по пренатальной диагностике.</p> <p>При гормональном исследовании крови по программе пренатальной диагностики &quot;АЛЬФА&quot; в срок беременности 16–17 нед от 8.02.99: концентрация a-фетопротеина – 37,6 МЕ/мл – 0,95 МОМ; ХГ – 47 340 МЕ/л – 1,64 МОМ; Е3 – 33,6 нмоль/л – 1,05 МОМ.</p> <p>Результат скрининга: риск рождения ребенка с болезнью Дауна 1:1 300; риск рождения ребенка с дефектом невральной трубки – 1:12 000.</p> <p>При УЗИ плода в срок беременности 23 и 34 нед патологии не выявлено.</p> <p>С целью исключения хромосомной патологии плода 19.01.99 беременной был произведен трансабдоминальный кордоцентез. Анализ кариотипирования лимфоцитов крови плода показал нормальный женский кариотип 46,ХХ, без числовых и структурных перестроек. Учитывая наличие нормального кариотипа у плода, женщина пролонгировала беременность.</p> <p>Роды произошли в срок беременности 38 нед. Родилась здоровая девочка массой 3300 г, длиной 54 см.</p> <p>Обсуждение</p> <p>По современным представлениям, гонады эмбриона с кариотипом 45,Х дегенерируют в позднем фетальном периоде или в раннем периоде новорожденности и представляют собой типичные гонады тяжи [1]. Период до полной атрезии всех фолликулов может длиться до 20 или 30 лет, поэтому существование активных фолликулов при дисгенезии гонад возможно и у взрослых индивидуумов. Клиническая картина зависит от структуры дисгенетичной гонады. Возможен спонтанный пубертат как в представленных случаях и/или ранняя вторичная аменорея. Так, A.M. Pasquino и соавт. сообщают о 522 девочках с синдромом Шерешевского–Тернера, старше 12 лет, не имеющих отчетливых признаков заболевания, с кариотипом 45,Х и 45,X/46,XX [12]. По данным этих авторов, у 84 больных был спонтанный пубертат с менархе в 13 лет. При этом костный возраст в среднем составил 12,9 года. Регулярный менструальный цикл сохранялся у 30 больных в среднем 9,2 года после менархе. Вторичная аменорея развилась в среднем через 1,6 года. У некоторых менструации приобрели нерегулярный характер через 9 мес. У 3 больных наступила беременность, которая закончилась в одном случае рождением здорового ребенка, в другом – рождением ребенка с синдромом Тернера и в третьем – рождением ребенка с врожденными пороками развития.</p> <p>C.Huseman [7] сообщает даже о случае с преждевременным пубертатом, с менархе в 10-месячном возрасте при кариотипе 45,Х/46,ХХ. Возможно имело место персистирование функционально полноценного фолликула при наличии клеточной линии с нормальным кариотипом.</p> <p>Отметим, что в представленных случаях у больных был мозаичный кариотип с преобладанием нормальной ХХ-клеточной линии в лимфоцитах периферической крови.</p> <p>Нормальное развитие яичников во время фетального периода с наступающей после рождения регрессией описано у девочек с хромосомной конституцией 46,X,i (Xq) [6].</p> <p>A.Farabosco и соавт. указывают, что хромосомные участки Xq13- больше q21 и Хq21- больше q26 ответственны за развитие фертильных гонад. Авторы приводят данные о фертильности женщин с гетерозиготным дефицитом сегмета Хр ter- больше p21 [5]. Возможно, гены, необходимые для поддержания функциональной способности ооцитов, локализованы между Хp21 и центромерой [6].</p> <p>Около 5–11% всех фертильных женщин с синдромом Шерешевского–Тернера имеют кольцевую хромосому Х с кариотипическим мозаицизмом 45Х/46,Х,r(X). Происхождение радиарной хромосомы обусловлено делецией обеих теломер или теломерных сегментов с присоединенным слиянием мест переломов хромосом X или Y [8].</p> <p>E.Bannier и соавт. [3] сообщают о случае передачи кольцевой хромосомы Х от фергильной матери к дочери. Современные методы определения происхождения подобной хромосомы (неауторадиографическая гибридизация in situ биотинированных Х (qSV2X5)- и Y (Y84)-специфических для центромер зондов) позволяют четко и быстро идентифицировать кольцо Х-происхождения [4] у матери и потомка.</p> <p>Описан также случай синдрома Шерешевского–Тернера у пробанда с кариотипом 45,Х/46,Х, del (X) (q21.2-q ter)/46,X, r(X), имеющего функциональную дисомию и изодисомию материнского происхождения [9], что указывает на возможность передачи аберрантной хромосомы от фертильнои матери к потомству.</p> <p>Ребенок от женщины с мозаичным вариантом синдрома Шерешевского–Тернера имел в нашем случае нормальный кариотип. Это позволяет считать, что созревшая яйцеклетка должна содержать неаберрантную хромосому Х. Эту мысль подтверждает A.Novac и соавт. [11] и A.Mori и соавт. [10], которые нашли разную патологию в хромосомном статусе периферической крови, кожных фибробластов, а также левой и правой гонад. Таким образом, кариотип, определенный в лимфоцитах периферической крови, не в каждом случае определяет ситуацию в гонадах.</p> <p>Заключение</p> <p>Наличие у женщин кариотипа с патологическим клоном клеток (с мозаичным или моносомным вариантом синдрома Шерешевского–Тернера) не исключает наступления у них спонтанных, неиндуцированных беременностей и рождения здоровых детей. Разнообразие в экспрессии клинической картину синдрома Шерешевского–Тернера удивительно. Оно не характеризуется только тернеровскими стигмами и степенью гонадальной дисгенезии. При синдроме Шерешевского–Тернера спонтанные менструации при патологической гоносомной конституции встречаются чаще, чем нормальная фертильность.</p> mybb@mybb.ru (Кети) Mon, 02 Apr 2012 15:25:32 +0400 https://sherishterner.nextbb.ru/viewtopic.php?pid=58#p58